Yimin Zou, University of California, San Diego, USA
I am interested in the wiring, function and disorders of neural circuits. My lab studies axon guidance, synapse formation and regeneration in the central nervous system. My lab pioneered the finding that the Wnt family morphogens are axon guidance molecules, directing the pathfinding and topographic projection of axons along the major axes of the central nervous system. We then found that planar cell polarity and apical-basal polarity signaling pathways steer growth cones. In addition, we showed that axon guidance molecules and their signaling pathways are reactivated in adult central nervous after traumatic injury and play important roles in functional recovery. More recently, we found that planar cell polarity signaling components play critical roles in glutamatergic synapse formation.
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